A Ca channel blocker, benidipine, increases coronary blood flow and attenuates the severity of myocardial ischemia via NO-dependent mechanisms in dogs
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چکیده
منابع مشابه
The effects of ATP-dependent potassium channel opener; pinacidil, and blocker; glibenclamide, on the ischemia induced arrhythmia in partial and complete ligation of coronary artery in rats
Objective(s): Electrical inhomogeneity between ischemic and non ischemic myocardium is the basis of arrhythmia which occurs following coronary artery occlusion. The leakage of potassium from the ischemic region to the non ischemic region is very effective in the generation of these arrhythmias. The aim of this study is to research the effect of ATP-dependent potassium (KATP) channel blocker (gl...
متن کاملMechanical compression elicits NO-dependent increases in coronary flow.
Our previous studies have demonstrated that a decrease in arteriolar diameter that causes endothelial deformation elicits the release of nitric oxide (NO). Thus we hypothesized that cardiac contraction, via deformation of coronary vessels, elicits the release of NO and increases in coronary flow. Coronary flow was measured at a constant perfusion pressure of 80 mmHg in Langendorff preparations ...
متن کاملExercise-induced myocardial ischemia. Importance of coronary blood flow.
T he onset of ischemia is thought to occur when myocardial oxygen demand exceeds supply. In an individual patient the ischemic threshold might be a reproducible measure that could be used in the short term to establish the efficacy of therapy. In clinical studies the operational definition of the onset of ischemia has been 0.1 mV of ST depression on the electrocardiogram. In earlier investigati...
متن کاملthe effects of atp-dependent potassium channel opener; pinacidil, and blocker; glibenclamide, on the ischemia induced arrhythmia in partial and complete ligation of coronary artery in rats
objective(s): electrical inhomogeneity between ischemic and non ischemic myocardium is the basis of arrhythmia which occurs following coronary artery occlusion. the leakage of potassium from the ischemic region to the non ischemic region is very effective in the generation of these arrhythmias. the aim of this study is to research the effect of atp-dependent potassium (katp) channel blocker (gl...
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14. Roberts WC, Buja LM: The frequency and significance of coronary arterial thrombi and other observations in fatal acute myocardial infarction. A study of 107 necropsy patients. Am J Med 52: 425, 1972 15. Roberts WC, Ferrans VJ, Levy RI, Fredrickson DS: Cardiovascular pathology in hyperlipoproteinemia. Anatomic observations in 42 necropsy patients with normal or abnormal serum lipoprotein pat...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1999
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(98)00556-7